BIOCARD Study Publication List

2026

  1. Archer D, Lorenz A, Sath A, Yang Y, Durant A, Wu Y, Kim M, Gao C, Ramadass K, Kanakaraj P,  Khairi N, Li Z, Yao T, Huo Y,  Dumitrescu L,  Shashikumar N, Pechman K, Risacher S, Beason-Held L, An Y, Arfanakis K, Erus G, Davatzikos C, Habes M, Wang D, Tosum D, Toga A, Thompson P, Mormino E, Zhang P, Schilling K,  Albert M, Kukull W, Biber S, Landman B, Johnson S, Bendlin B, Schneider J, Bennett D, Jefferson A, Resnick S, Saykin A, Below J, Hohman H. Genetic architecture of the limbic white matter microstructure in aging and Alzheimer’s Disease, Alzheimer’s & Dementia, in press.
  2. Archer D, Peterson A, Sathe A, Zaras D, Yang Y, Durant A, Deters K, Shashikumar N, Pechman K, Kim M, Gao C, Khairi N, Li Z, Yao T, Huo Y, Dumitrescu L, Gifford K, Wilson J, Cambronero F, Risacher S, Beason-Held L, An Y, Arfanakis K, Erus G,  Davatzikos C, Tosun D, Toga A, Thompson P, Mormino E, Habes M, Wang D, Zhang P, Schilling K, Albert M, Kukull W, Biber S, Landman B, Johnson S, Schneider J, Barnes L, Bennett D, Jefferson A, Resnick S, Saykin A, Hohman T. Sex and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer’s disease. Alzheimer’s & Dementia, in press.
  3. Benina N, Buitrago L, De Simone F, Radwan R, Miller C, Martin K, DicksonD. HoS, Moghekar A, Albert M, Mattsson-CarlgrenN, Palmqvist S, OssenkoppeleR, Jonsson M,  Hansson O, Stomrud E, SachdevP, NiuH, VerbelD, HawkinsD. Plasma pTau 217/Aβ 1-42 ratio for enhanced accuracy and reduced uncertainty in detecting amyloid pathology. Brain, 2026; 149:1168-1181. PMCID: PMC13058457.
  4. Callow D, Rani N, Alm K, Pettigrew C, Miller M, Albert M, Bakker A, Soldan A. Hippocampal microstructure as a measure of cognitive resilience to tau PET burden in older adults, Journal of Prevention of Alzheimer’s Disease, 2026; 13: 100454. PMCID: PMC12869048.
  5. CallowD, Rani N, SmithJC, SoldanA, Pettigrew C, Spira A, Albert M, Bakker A. APOE ε4 and amyloid status moderate the associations between physical activity, sleep, and tau-PET burden in cognitively unimpaired older adults. Alzheimer’s & Dementia, in press
  6. Contreras, A. G., Walters, S., Eissman, J. M., Archer, D. B., Regelson, A. N., Durant, A., Clifton, M., Mukherjee, S., Lee, M. L., Choi, S.-E., Scollard, P., Trittschuh, E. H., Mez, J., Bush, W. S., Kunkle, B. W., Naj, A. C., Gifford, K. A., Bilgel, M., Kuzma, A. B, Cuccaro, M. L., Pericak-Vance, M. A., Farrer, L. A., Wang, L.-S., Schellenberg, G. D., Haines, J. L., Albert, M. S., Johnson, S. C., Engelman, C. D., Ferrucci, L., Bennett, D. A., Barnes, L. L., Schneider, J. A., Sperling, R. A., Resnick, S. M., Crane, P. K., Dumitrescu, L., & Hohman, T. J. Genetic modifiers of APOE-ε4-associated cognitive decline. Nature Communications, 2026, 17:2982. PMCID: PMC13036010.
  7. Durant A, Mukherjee S, Lee M, Choi S, Scollard P, Klinedinst B, Trittschuh E, Mez J,  Farrer L, Gifford K, Cruchaga C, Hassenstab J, Naj A, Wang L-S, Johnson S, Engelman C,  Kukull W, Keene K, Saykin A, Cuccaro M,  Kunkle B, Pericak-Vance M,  Martin E, Bennett D, Barnes L, Schneider J, Bush W, Haines J, Mayeux R,  Vardarajan B, Albert M, Paul M, Thompson P, Jefferson A, Crane P, Dumitrescu L, Archer D, Hohman T, Gaynor L.  Evaluating the association of APOE genotype and cognitive resilience in Superagers, Alzheimer’s & Dementia, 2026; 22: e71024. PMCID: PMC12809718
  8. Eissman JM, Regelson AN, Walters S, Archer DB, Durant A, Mukherjee S, Lee ML, Choi S-E, Scollard P, Trittschuh EH, Mez J, Kang M, Bush WS, Kunkle BW, Naj AC, Gifford KA, Bilgel M, Kuzma AB, Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang L-S, Schellenberg GD, Vardarajan BN, Mayeux R, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Albert MS, Johnson SC, Engelman CD, Ferrucci L, Bennett DA, Barnes LL, Schneider JA, Resnick SM, Sperling RA, Crane PK, Hohman TJ, Dumitrescu L. Sex-specific genetic drivers of memory, executive functioning and language in older adults. Brain, 2026; awag137.
  9. Jhaldiyal A, Kumari M, Guttman L, Tripathi T, Khan M, Wang J, Biswas D, Pasupuleti A, Aggarwal A , Pandya S, Chou S-C, Panicker N, Moghekar A, Albert M, Bekris L, Leverenz J, Kam T-I, Dawson T, Dawson V. PARP 1 deficiency mitigates amyloid pathology, neurodegeneration and cognitive decline in a familial Alzheimer’s disease model. PNAS, 2026, 123: e2525028123.
  10. PaitelE, Pettigrew C, Moghekar A, MillerM, FariaA, AlbertM, NaC-H, Worley P, Soldan A. Associations of cerebrospinal fluid measures of synaptic function with white matter microstructure and cognition in older adults. Frontiers in Aging Neuroscience, in press
  11. Rani N, Moghekar A, Callow D, Alm K, Pettigrew C, Soldan A,, Miller M,, Wang J, Lodge M, Albert M, Bakker A. Association between longitudinal rate of change in cerebrospinal fluid biomarkers and subsequent tau PET burden in early Braak stages. Neurology, 2026; 106: e214620. PMCID: PMC1287810.
  12. Rani N, Alm K, Callow D, Zhu Y, Pettigrew C, Soldan A, Lodge M, Miller M, Albert M, Bakker A. Tau burden across Braak stages is associated with regionally specific amyloid accumulation. Brain Communications, in press
  13. Vazquez J, PettigrewC, ZhuY, AndersonC, ErusG, DavatzikosC, Miller M, Moghekar A, OhS, Na C-H, AlbertM, Worley P, Soldan A. CSF levels of NPTX2 are associated with less brain atrophy over time in cognitively unimpaired individuals. Annals of Clinical and Translational Neurology, 2026; 13:332-342. PMCID: PMC12883677.
  14. Wang K, Zhu Y, Albert M, Miller M, Davatzikos C, Moghekar A, SoldanA, Wang M-C. Modeling the age-specific incidence of mild cognitive impairment incorporating the time-varying relationship of Alzheimer’s disease biomarkers over 28 years. Journal of Alzheimer’s Disease, 2026; 109: 483-493.
  15. Wu J, Oishi K, Soldan A, Pettigrew C, Lin Z, Zhu Y, Jiang D, Li X, Gou Y, Moghekar A, Liu P, Bakker A, Oishi K, Albert M, Lu H. Five-year change in brain metabolism across the spectrum of cognitive impairment in older adults: a quantitative MRI study, Alzheimer’s & Dementia, in press.
  16. Xie S, Liang Y, Pang Y, Li Y, Cao S, Li Y, Wang Q, Moghekar A, Albert M, Jia J. Plasma biomarker trajectories across Alzheimer’s clinical onset: a 17-year prospective study. Alzheimer’s Research and Therapy, 2026, 18: 137. PMCID: PMC13231753
  17. Yang B, Earnest T, Bilgel M, Albert M, Johnson S, Davatzikos C, Erus G, Masters C, Resnick S, Miller M, Bakker A, Morris J, Benzinger T; Gordon B; Sotiras A. Predicting future cognitive impairment in preclinical Alzheimer’s disease using multimodal imaging: a multisite machine learning study, Neurobiology of Aging, 2026, 165: 8-23. PMCID: PMC12633089.


    2025
  18. Anderson C, Gross A, Pettigrew A, Vazquez J, Wang H, Moghekar A, Oh S, Na C-H, Albert M, Worley P, Soldan A. Cognitive resilience in preclinical Alzheimer’s disease: Higher NPTX2 and VGF levels are associated with reduced cognitive decline. Neurobiology of Aging, 2025; 156: 133-142. PMCID: PMC12687933.
  19. Barough S, Bilgel M, Ventura C, An L, Albert M, Miller M, Luciano M, Moghekar A. Automated deep learning pipeline for callosal angle quantification. Fluids & Barriers CNS, 2025; 23: 17. PMCID: PMC12853608.
  20. Callow D, Spira A, Zipunnikov V, Pettigrew C, Faria A, Wanigatunga S, Rabinowitz J, Albert M, Bakker A, Soldan A. Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle age and older adults. Neurobiology of Aging, 2025; 147: 22-31. PMCID: PMC11783188.
  21. Callow D, Pettigrew C, Zipunnikov V, Wanigatunga S, Albert M, Bakker A, Soldan A, Spira A. White matter microstructure statistically mediates associations between circadian rest activity rhythms and cognition in older adults. Sleep Advances, 2025; 6: zpaf027. PMCID: PMC12131157.
  22. Callow D, Rani N, Alm K, Pettigrew C, Soldan A, Sheikhbahaei S, Miller M, Albert M, Bakker A. Tau PET burden is associated with hippocampal microstructure and episodic memory in amyloid positive older adults. Hippocampus, 2025; 35: e70038. PMCID: PMC12536762.
  23. Castellano T, Wang TC, Nolan E, Wu Y, Zhang M, Clifton M, Janve VA, Durant A, Regelson A, Cody K, Harrison T, Engelman CD, Jagust W, Albert M, Johnson S, Resnick SM, Sperling R, Bilgel M, Saykin A, Vardarajan B, Mayeux R; Betthauser T, Bennett DA, Schneider J, De Jager P, Menon V, Tosun D, Mormino E, Archer DB, Dumitrescu L, Hohman TJ, Koran ME. APOE, ABCA7, and RASGEF1C are associated with earlier onset of amyloid deposition from over 4000 harmonized Positron Emission Tomography images. Alzheimers Dement, 2025; 21: e71006. PMCD12701365.
  24. Chen L, Soldan A, Faria A, Albert M, vanZijl, P, Li X. Susceptibility MRI predicts mild cognitive impairment onset and cognitive decline in cognitively unimpaired older adults, Radiology, 2025; 316: e250513. PMCID: PMC12501624
  25. Dougherty R, Soldan A, Pettigrew C, Greenberg B, Spira A, Moghekar A, Albert M. Physical activity attenuates the association of CSF tau and executive function. Alzheimer’s Dementia: Translational Research Clinical Investigations, 2025; 11: e70085. PMCID: PMC12000248.
  26. Gao C, Kim M, Ramadass K, Kanakaraj P, Krishman A, Saunders A, Newlin N, Lee H, Yang Q, Taylor W, Boyd B, Beason-Held L, Resnick S, Barnes L, Bennett D, Albert M, Schaik K, Archer D, Hohman T, Jefferson A, Isgum I, Moyer D, Huo Y, Shilling K, Zuo L, Bao S, Khairi N, Li Z, Davatzikos C, Landman B. Brain age identification from diffusion MRI synergistically predicts neurodegenerative disease. Imaging Neuroscience, 2025; 3. PMCID: PMC12320004.
  27. Govindarajan S, Mamourian E, Erus G, Abdulkadir A, Melhem R, Tosun-Turgut D, Bilgel M, An Y, Sotiras A, Marcus D, LaMontagne P, Benzinger T, Espeland M, Masters C,  Maruff P,  Fripp J,  Johnson S,  Morris J, Albert M,  Bryan N,  Resnick S,  Habes M,  Haochang S,  Wolk D,  Nasrallah I,  Davatzikos C.  Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals. Nature Communic, 2025; 16: 2724. PMCID: PMC11923046.
  28. Hahn A, Volk, H, Pettigrew C, Faria A, Bilgel M, Lu H, Miller M, Albert M, Soldan A. Cognitive profiles among dementia-free older adults and their associations with neuroimaging markers. Brain Imaging and Behavior, 2025; 10.1007. PMCID: PMC12688011.
  29. Hayes-Larson E, Andrews RM, Kezios KL, Bercu A, Rouanet A, Helmer C, Crane PK, Gibbons L, Klinedinst BS, McKevoy LK, Nichols E, Weuve J, Rajan KB, Hwang PH, Mez J, Farina M, Shaw C, Sims KD, Therneau T, Petersen RC, Bouteloup V, Gross A, Albert M, Morris JC, Masters CL, Resnick SM, Maruff P, Manly JM, Turney IC, Vonk JMJ, Avila-Rieger J, Weigand A, Chen R, Wang J, Proust-Lima C, Mayeda ER. Approaches to timescale choice in cognitive aging research and potential implications for estimated exposure effects: coordinated analyses in ten cohorts of older adults. Epidemiology. 2025; 36: 560-571. PMCID: PMC1221680.
  30. Lorenz A, Sathe A, Zaras D, Yang Y, Durant A, Kim M, Gao C, Newlin N, Ramadass K, Kanakaraj P, Khiari N, Li Z, Yao T, Huo Y, Dumitrescu L, Shashikumar N, Pechman K, Jackson T, Workmeister A, Risacher S, Beason-Held L, An Y, Arfanaks K, Erus G, Davatzikos C, Habes M, Wang D, Tosum D, Toga A, Thompson P, Mormino E, Zhang P, Schilling K, Albert M, Kukull W, Biber S, Landman B, Johnson S, Bendlin B, Schneider J, Barnes L, Bennett D, Jefferson A, Resnick S, Saykin A, Hohman T, Archer D. The effect of Alzheimer’s disease genetic factors on limbic white matter microstructure. Alzheimers Dement, 2025, 21: e70130. PMCID: PMC11992597.
  31. Mueller K, Soldan A, Langhough R, Bruno D, Jaureg A, Basche K, Hale M, He D,  Moghekar A, Hermann B, Albert M, Pettigrew C. Proper name recall as an early indicator of preclinical Alzheimer’s Disease pathology. Alzheimer’s Disease and Associated Disorders, 2025; 39: 269-276. PMCID: PMC12154997.
  32. Paitel E, Pettigrew C, Moghekar A, Miller M, Faria A, Albert M, Soldan A. Alzheimer’s disease cerebrospinal fluid biomarkers and APOE genetic status impact hippocampal-cerebellar functional connectivity, Neurobiology of Aging, 2025; 151: 107-116. PMCID: PMC12101073.
  33. Paitel E, Pettigrew C, Callow D, Moghekar A, Miller M, Faria A, Oishi K, Albert A, Soldan A. Cerebellar white matter microstructure is associated with age, cerebrospinal fluid amyloid beta levels, and cognition in cognitively unimpaired older adults. Human Brain Mapping, 2025; 46: e70398. PMCID: PMC2580907.
  34. Peter C, Sathe A, Zaras D, Yang Y, Durant A, Shashikumar N, Pechman K,Workmeister A, Jackson T, Kanarkaraj P, Kim M, Gao C, Newlin N, Ramadass K, Khairi N, Li Z, Yao T, Huo Y, Mukherjee S, Choi S-E, Klinedinst B, Lee M, Schollard P, Trittschuh E, Sanders E, Mez J, Dumitrescu L, Gifford K, Bolton C, Gaynor L, Risacher S, Beason-Held L, An Y, Arfanakis K, Erus G, Davatzikos C, Tosun D, Habes M, Wang D, Toga A, Thompson P, Zhang P, Schilling K, Albert M, Kukull W, Biber S, Landman B, Bendlin B, Johnson S, Schneider J, Barnes L, Bennett D, Jefferson A, Resnick S, Saykin A, Crane P, Cuccaro M, Hohman T, Archer D.  White Matter abnormalities and cognition in aging and Alzheimer’s disease. JAMA Neurology, 2025; e251601. PMCID: PMC12150229
  35. Peterson A, Sathe A, Zaras D, Yang Y, Durant A, Deters K, Shashikumar N, Pechman K, Kim M, Gao C, Khairi N, Li Z, Yao T, Huo Y, Dumitrescu L, Gifford K, Wilson J, Cambronero F, Risacher S, Beason-Held L An Y, Arfanakis K, Erus G, Davatzikos C, Tosum D, Toga A, Thompson P, Mormino E, Zhang P, Schilling K, Albert M, Kukull W, Biber S, Landman B, Johnson S, Schneider J, Barnes L, Bennett D, Jefferson A, Resnick S, Saykin A, Hohman T, Archer D Sex and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer’s disease. Alzheimer’s Dement, 2025; 21: e143443. PMCID: PMC1178133
  36. Pettigrew C, Soldan A, Wang J, Hohman T, DumitrescuL, Albert M, Blennow K, Bittner T, Moghekar A. Plasma biomarker trajectories: Impact of AD genetic risk and clinical progression. Alzheimer’s & Dementia: Diagnosis Assessment and Disease Monitoring, 2025; 17, e70081. PMCID: PMC11947672  
  37. Phillips J, Dumitrescu L, Archer D, Regelson A, Mukherjee S,, Lee M, Choi S-E, Schollard P, Trittschuh E, Kukull W, Biber S, Mez J, Mahoney E, Clifton M, Libby J, Walters S, Bush W, Engelman C, Lu Q, Fardo D, Widaman K, Buckley R, Mormino E, Sanders RE, Clark L, Gifford K, Vardarajan B, Cuccaro M, Pericak-Vance M, Farrer L, Wang L-S, Schellenberg G, Haines J, Jefferson A, Johnson S, Albert M, Keene CK, Saykin A, Risacher S, Larson E, Sperling R, Mayeux R, Goate A, Renton A, Marcora E, Fulton-Howard B, Patel T, Bennett D, Schneider J, Barnes L, Cruchaga C, Hassenstab J, Belloy M, Andrews S, Resnick S, Bilgel M, Yang A, Beason-Held L, Walker K, Duggan M, Kleindinst B, Crane P, Hohman T. Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer’s disease. Brain, 2025; 148: 2714-2729. PMCID: PMC12295682.
  38. Schilling K, Ramadass K, Sairanen V, Kim M, Rheault F, Newlin N, Nguyen T, Barquero L, D’Archangel M, Gao C, Topolnjak E, Khairi N, Archer D, Beason-Held L, Resnick S, Hohman T, Cutting L, Schneider J, Barnes L, Bennett D, Arfanakis K, Vinci-Booher S, Albert M, Landman B. Head motion in diffusion MRI: Quantification, mitigation, and structural associations in a large, cross-sectional dataset of lifespan and special populations. Hum Brain Mapp. 2025;46:e70143. PMCID: PMC11814480.
  39. Soldan A, Pettigrew C, Wang J, Albert M, Blennow K, Bittner T, Moghekar A. Blood-based biomarkers and risk of onset of mild cognitive impairment over the short and long-term, Neurology, 2025; 104: e210225. PMCID: PMC11714431
  40. Uchida Y, Hou Z, Gomez-Isaza L, Luongo M, Troncoso JC, Miller MI, Mori S, Oishi K. Quantification of perforant path fibers for early detection of Alzheimer’s disease. Alzheimers Dement 2025; 21, e70142. PMCID: PMC11972979.
  41. Uchida Y, Nishimaki K, Soldan A, Pettigrew P, Moghekar A, Miller M, Albert M, Oishi K. Changepoints in dynamic biomarkers of the Alzheimer’s pathological cascade: a 30-year longitudinal study. Alzheimer’s Dement, 2025; 21: e70544. PMCID: PMC12311614
  42. Xu X, Kiwon J, Yan R, Aplo C, Song S, Geo G, Yang Q, Timsina J, Liu M, Budde J, Blennow K, Zetterberg H, Lleo A, Ruia A, Molineuvo J, Lee V, Deming Y, Hesegrave A, Hohman T, Pastor P, Peskind E, Albert M, Morris C, Park T, Cruchaga D, Sung Y. Sex differences in Apolipoprotein E and Alzheimer’s Disease Pathology Across Ancestries. JAMA Network Open, 2025; 8: e250562. PMCD: PMC11897841.
  43. Zhang X, Caffo B, Soldan A, Pettigrew C, Guray E, Davatzikos C, Morris J, Benzinger T, Johnson S, Masters C, Fripp J, Resnick S, Bilgel M, Kukull W, Albert M, Wang Z. MRI distance measures as a predictor of subsequent clinical status during the preclinical phase of Alzheimer’s disease and related disorders. Human Brain Mapping, 2025; 46: e70205. PMCID: PMC12018902.


    2024
  44. Callow D, Spira A, Zipunnikov V, Lu H, Wanigatunga S, Rabinowitz J, Albert M, Bakker A, Soldan A. Sleep and physical activity measures are associated with resting-state network segregation in non-demented older adults. Neuroimage Clinical, 2024; 43: 103621. PMCID: PMC11179421
  45. Callow D, Zippunikov V, Spira A, Wanigatunga S, Pettigrew C, Albert M, Soldan A.  Activity estimates of sleep quality moderates the relationship between physical activity and cognition in older adults. Mental Health and Physical Activity, 2024; 10573. PMCID: PMC10803079
  46. Ho S, Darrow J, De Simone F, Calabro A, Gannon S, Esquivel R, Thakker P, Khingelova K, Rao A, Zhang Y, Moghekar A.  Assessment of pre-analytic cerebrospinal fluid handling and storage factors on measurement of Abeta 1-42, Abeta 1-40, p-tau 181 using an automated chemiluminescent platform. Appl Lab Med. 2024; 9: 789-802.
  47. Skampardoni I, Nasrallah I, Abdulkadir A, Wen J, Melhem R, Mamourian E, Erus G, Doshi J, Singh A, Yang Z, Cui Y, Hwang G, Ren Z, Pomponio R, Srinivasan D, Govindarajan S, Parmpi P, Wittfeld K, Grabe H, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Marcus D, LaMontagne P.  Heckbert S, Austin T, Launer L, Sotiras A, Espeland M, Masters C, Maruff P, Fripp J, Johnson S, Morris J, Albert M, Bryan N, Yaffe K, Völzke H, Ferrucci L, Benzinger T, Ezzati A, Shinohara R, Fan Y, Resnick S, Habes M, Wolk D, Shou H, Nikita K, Davatzikos C. Genetic and clinical correlates of AI-based aging patterns in cognitively unimpaired individuals. JAMA Psychiatry, 2024; 81: 456-467. PMCID: PMC10867776
  48. Soldan A, Wang J, Pettigrew C, Davatzikos C, Erus G, Hohman T, Dumitrescu L, Bilgel M, Resnick S, Rivera-Rivera L, Langhough R, Johnson S, Benzinger T, Morris J, Laws S, Fripp J, Masters C, Albert M. Alzheimer disease genetic risk and changes in brain atrophy and WMH in cognitively unimpaired adults. Brain Communications, 2024; 6: fcae276. PMCID: PMC11369827
  49. Stouffer K, Grande X, Duzel E, Johansson M, Creese B, Witter M, Miller M, Wisse L, Berron D. Amidst an amygdala renaissance in Alzheimer’s disease. Brain, 2024; 147: 816-829. PMCID: PMC10907090.
  50. Uchida Y, NishimakiK, Soldan A, Moghekar A, Albert M, Oishi, K. Acceleration of brain atrophy and progression from normal cognition to mild cognitive impairment. JAMA Network Open, 2024, 7: e2441504. PMCID: PMC11525609.
  51. Wen J, Yang Z, Nasrallah IM, Cui Y, Erus G, Srinivasan D, Abdulkadir A, Mamourian E, Hwang G, Singh A, Bergman M, Bao J, Varol E, Zhou Z, Boquet-Pujadas A, Chen J, Toga AW, Saykin AJ, Hohman TJ, Thompson PM, Villeneuve S, Gollub R, Sotiras A, Wittfeld K, Grabe HJ, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Benzinger TL, Heckbert SR, Austin TR, Launer LJ, Espeland M, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Resnick SM, Ferrucci L, Fan Y, Habes M, Wolk D, Shen L, Shou H, Davatzikos C. Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer’s disease continuum. Transl Psychiatry. 2024; 14: 420. PMCID: PMC11455841.
  52. Yang Z, Wen J, Abdulkadir A, Cui Y, Erus G, Mamourian E, Melhem R, Srinivasan D, Govindarajan ST, Chen J, Habes M, Masters CL, Maruff P, Fripp J, Ferrucci L, Albert MS, Johnson SC, Morris JC, LaMontagne P, Marcus DS, Benzinger TLS, Wolk DA, Shen L, Bao J, Resnick SM, Shou H, Nasrallah IM, Davatzikos C. Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering. Nature Communications. 2024;15: 354. PMCID: PMC10774282
  53. Yang Z, Wen J, Erus G, Govindarajan ST, Melhem R, Mamourian E, Cui Y, Srinivasan D, Abdulkadir A, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Yi D, Marcus DS, LaMontagne P, Benzinger TLS, Heckbert SR, Austin TR, Waldstein SR, Evans MK, Zonderman AB, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Toga AW, O’Bryant S, Chakravarty MM, Villeneuve S, Johnson SC, Morris JC, Albert MS, Yaffe K, Völzke H, Ferrucci L, Nick Bryan R, Shinohara RT, Fan Y, Habes M, Lalousis PA, Koutsouleris N, Wolk DA, Resnick SM, Shou H, Nasrallah IM, Davatzikos C. Brain aging patterns in a large, diverse cohort of 49,482 individuals. Nat Med. 2024; 10: 3015-3026. PMCID: PMC11483219


    2023
  54. Kamalian A, Ho S, Patel M, Lewis A, Bakker A, Albert M, O’Brien R, Moghekar A, Lutz M. Exploratory assessment of proteomic network changes in cerebrospinal fluid of mild cognitive impairment patients: a pilot study. Biomolecules, 2023; 13:1094. PMCID: PMC10377001
  55. Lin Z, Lim C, Jiang D, Soldan A, Pettigrew C, Oishi K, Liu P, Albert M, Lu H. Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: relationship to vascular and Alzheimer’s pathology. Alzheimer’s & Dementia, 2023; 19:569-577. PMCID: PMC10838398
  56. Newton P, Tchounguen J, Pettigrew C, Lim C, Lin Z, Lu H, Moghekar A, Albert M, Soldan A. Regional white matter hyperintensities and Alzheimer’s disease biomarkers among older adults with normal cognition and mild cognitive impairment. Journal of Alzheimer’s Disease, 2023; 92: 323-339. PMCID: PMC10041440
  57. Pettigrew C, Nazarovs J, Soldan A, Singh V, Wang J, Hohman T, Dumitrescu L, Libby J, Kunkle B, Gross A, Johnson S, Lu Q, Engelman C, Masters C, Maruff P, Laws S, Morris J, Hassenstab J, Cruchaga C, Resnick S, Kitner-Triolo M, An Y, Albert M. Alzheimer’s disease genetic risk and cognitive reserve in relationship to cognitive trajectories among cognitively normal individuals. Alzheimer’s Research and Therapy, 2023;15:66. PMCID: PMC10045505
  58. Rani N, Alm K, Corona-Long C, Speck C, Soldan A, Pettigrew C, Zhu Y, Albert M, Bakker A. Tau accumulation in Brodmann areas 35 and 36 is associated with individual differences in cognition in non-demented older adults. Frontiers in Aging Neuroscience,2023; 15: 1272946. PMCID: PMC10757623
  59. Soldan A, Oh S, Ryu T, Pettigrew C, Zhu Y, Moghekar A, Xiao M-F, Pontone G, Albert M, Na C-H, Worley P. NPTX2 in cerebrospinal fluid predicts progression to mild cognitive impairment, Annals of Neurology, 2023; 94:620-631. PMCID: PMC10543570
  60. Stouffer K, Chen C, Kulason S, Xu E, Witter M, Ceritoglu C, Albert M, Mori S, Troncoso J, Tward D, Miller M. Early amygdala and ERC atrophy linked to 3D reconstruction of rostral tau tangle neurofibrillary pathology in Alzheimer’s disease. Neuroimage Clinical, 2023; 38: 103374. PMCID: PM10034129
  61. Sun Y, Moghekar A, Soldan A, Pettigrew C, Greenberg B, Albert M, Wang M-C. Cerebrospinal fluid Alzheimer’s disease biomarkers patterns of change prior to the onset of mild cognitive impairment. Journal of Alzheimer’s Disease, 2023; 96:287-300. PMCID: PMC10793182
  62. Uchida Y, Onda K, Hou Z, Troncoso J, Mori S, Oishi K. Microstructural neurodegeneration of the entorhinal-hippocampus pathway along the Alzheimer’s disease continuum. J Alzheimers Dis 2023; 95, 1107-1117. PMCID: PMC10578220.
  63. Wen J, Nasrallah IM, Abdulkadir A, Satterthwaite TD, Yang Z, Erus G, Robert-Fitzgerald T, Singh A, Sotiras A, Boquet-Pujadas A, Mamourian E, Doshi J, Cui Y, Srinivasan D, Skampardoni I, Chen J, Hwang G, Bergman M, Bao J, Veturi Y, Zhou Z, Yang S, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, Meisenzahl E, Busatto GF, Crespo-Facorro B, Pantelis C, Wood SJ, Zhuo C, Shinohara RT, Gur RC, Gur RE, Koutsouleris N, Wolf DH, Saykin AJ, Ritchie MD, Shen L, Thompson PM, Colliot O, Wittfeld K, Grabe HJ, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Espeland M, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Resnick SM, Fan Y, Habes M, Wolk D, Shou H, Davatzikos C. Genomic loci influence structural patterns in the human brain. Proc Natl Acad Sci U S A. 2023;120(52):e2300842120. PMCID: PMC 10756284



    2022
  64. Alm K, SoldanA, PettigrewC, FariaA, HouX, LuH, Moghekar A, MoriS, Albert M, BakkerA. Structural and functional brain connectivity uniquely contribute to episodic memory performance in older adults. Frontiers in Aging Neuroscience, 2022; 14: 951076. PMCID: PMC9315224.
  65. Bashyam V, Doshi J, Erus G, Srinivasan D, Abdulkadir A, Habes M, Fan Y, Launer L, Masters C, Maruff P, Zhuo C, Völzke H, Johnson S, Fripp J, Koutsouleris N, Satterthwaite T, Wolf D, Gur R,  Gur R, Morris J, Albert M, Grabe H, Resnick S, Bryan RN,  Wolk D, Shou H, Nasrallah I, Davatzikos C, Deep generative medical image harmonization for improving cross-site generalization in deep learning predictors. Magnetic Resonance Imaging, 2022; 5: 908-916. PMCID: PMC8844038.
  66. Betthauser T, Bilgel M, Koscik R, Jedynak B, An Y, Kellett K, Moghekar A, Jonaitis E, Stone C, Engelman C, Asthana S, Christian B, Wong D, Albert M, Resnick S, Johnson S. Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts. Brain 2022; 145:4065-4079. PMCID: PMC9679170
  67. Brichko R, Soldan A, Zhu Y, Wang MC, Faria A, Albert M, Pettigrew C. Age-dependent association between cognitive reserve proxy and longitudinal white matter microstructure in older adults. Frontiers in Psychology, 2022; 13: 859826. PMCID: PMC8210464.
  68. Chan C, Pettigrew C, Soldan A, Zhu Y, Wang M-C, Albert M, Rosenberg P. Association between late life neuropsychiatric symptoms and cognitive decline in relation to white matter hyperintensities and amyloid burden, Journal of Alzheimer’s Disease, 2022; 86: 1415-1426.  PMCID: PMC9969328.
  69. Greenberg BD, Pettigrew C, Soldan A, Wang J, Wang MC, Darrow J, Albert M, Moghekar A. CSF Alzheimer’s Disease biomarkers: Time-varying relationships with MCI symptom onset, and associations with age, sex and ApoE4. Neurology, 2022; 99: e1640-e1650. PMCID: PMC9559947
  70. Han H, Lin Z, Soldan A, Pettigrew C, Betz JF, Oishi K, Li Y, Liu P, Albert M, Lu H. Longitudinal changes in global cerebral blood flow in cognitively normal older adults: A phase-contrast MRI study. Journal of Magnetic Resonance Imaging, 2022; 56: 1538-1545. PMCID: PMC9411265
  71. Hwang G, Abdulkadir A, Erus G, Habes M, Pomponio R, Shou H, Doshi J, Mamourian E, Rashid T, Bilgel M, Fan Y, Sotiras A, Srinivasan D, Morris J, Albert M, Bryan N, Resnick S, Nasrallah I, Davatzikos C, Wolk D. Disentangling Alzheimer’s disease neurodegeneration from typical brain aging using machine learning. Brain Communications, 2022; 4: fcac117. PMCID: PMC912389
  72. Luo J, Agboola F, Grant E, Morris J, Masters C, Albert M, Johnson S, McDade E, Fagan A, Benzinger T,  Hassenstab J,  Bateman R, Perrin R, Wang G, Li Y, Gordon B, Cruchaga C, Day G, Levin J,  Vöglein J, Ikeuchi T,Suzuki K, Allegri R, Xiong C. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan, Brain, 2022, 145: 4459-4473. PMCID: PMC10200301
  73. Oishi K, Soldan A, Pettigrew C, Hsu J, Mori S, Albert M, Oishi K. Changes in pairwise functional connectivity associated with changes in cognitive performance in cognitively normal older individuals: A two-year observational study. Neuroscience Letters, 2022; 781:136618. PMCID: PMC9990522.
  74. Pettigrew C, Soldan A, Brichko R, Zhu Y, Wang M-C, Kutten K, Bilgel M, Mori S, Miller M, Albert M. Computerized paired associate learning performance and imaging biomarkers in older adults without dementia. Brain Imaging and Behavior, 2022; 16: 921-929. PMCID: PMC9012682.
  75. Pettigrew C, Soldan A, Wang J, Wang M-C, Greenberg B, Albert M, Moghekar A. Longitudinal CSF Alzheimer’s biomarker changes from middle age to late adulthood. Alzheimer’s & Dementia: Diagnosis, Assessment and Disease Monitoring, 2022; 14: e12374. PMCID: PMC9673459
  76. Seto M, Mahoney ER, Dumitrescu L, Ramanan VK, Engelman CD, Deming Y, Albert M, Johnson SC, Zetterberg H, Blennow K, Vemuri P, Jefferson AL, Hohman TJ. Exploring genetic contributors to neuroprotection from amyloid pathology. Brain Communications, 2022; 4: fcac066. PMCID: PMC9006043
  77. Soldan A, Alfini A, Pettigrew C, Faria A, HouX, LimC, LuH, Spira A, ZipunnikovV, AlbertM. Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults, Neurobiology of Aging, 2022;116: 32-40.  PMCID: PMC10167793
  78. Stouffer, K. M., Witter, M. P., Tward, D. J. Miller, M. I. Projective Diffeomorphic Mapping of Molecular Digital Pathology with Tissue MRI. Commun Eng, 2022;  1:44. PMCID: PMC10243734.
  79. Wen J, Fu C, Tosun D, Veturi Y, Yang Z, Abdulkadir A, Mamourian E, Srinivasan D,  BaoJ, Erus G,  ShouH, HabesM, Doshi J, VarolE, MackinS, Sotiras A, Fan Y, SaykinA, ShelineY, ShenL, RitchieM, WolkD, AlbertM, Resnick S, Davatzikos C. Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with later-life depression.  JAMA Psychiatry, 2022; 79: 464-474. PMCID: PMC8908227
  80. Zhu Y, Wang MC. Obtaining optimal cutoff values for tree classifiers using multiple biomarkers. Biometrics, 2022; 78: 128-140. PMCID: PMC8557826



    2021
  81. AlfiniA, Albert  M, FariaA, Soldan A, PettigrewC, WanigatungaS , ZipunnikovV,  SpiraA. Associations of actigraphic sleep and circadian rest/activity rhythms with cognition in the early phase of Alzheimer’s disease. Sleep Advances, 2021; 2: zpab007. PMCID: PMC8168567.
  82. Byeon S, Madugundu A, Jain A, Bhat F, Jung J, Renuse S, Darrow J, Bakker A, Albert M, Moghekar A, Pandey A. Cerebrospinal fluid lipidomics for biomarkers of Alzheimer’s disease. Molecular OMICS, 2021, 17: 454-463. PMCID: PMC8210464.
  83. Chen L, Soldan A, Oishi K, Faria A, Zhu Y, Albert M, vanZijl P, Li X. Quantitative susceptibility mapping of brain iron and beta-amyloid in MRI and PET relating to cognitive performance in cognitively normal older adults. Radiology, 2021; 298: 353-362. PMCID: PMC7850239
  84. Darrow J, Calabro  A, Gannon  A,  Orusakwe  A, EsquivelR,  TraynhamCJ,  RaoA,  GulyaniA,  Khingelova  K,  Bandeen-Roche K,  Albert  M,  Moghekar A. Effect of patient specific pre-analytic variables on CSF Aβ1-42 concentrations measured on an automated chemiluminescent platform, Journal of Applied Laboratory Medicine, 2021; 6: 397-408.  PMCID PMC8482291 
  85. Habes M, Pomponio R, ShouH, Doshi J, Mamourian L, ErusG, Nasrallah I,  Launer L, RashidT, BilgelM, FanY, Toledo J, YaffeK, Sotiras A, SrinivasanD, EspelandM, MastersC, VölzkH, JohnsonS, Morris J, Albert M, Miller M, BryanN, GrabeH, ResnickS, Wolk D,  Davatzikos C. The Brain Chart of Aging: Machine learning analytics reveals links between brain aging, white matter disease, amyloid burden and cognition in the iStaging consortium of 10,215 harmonized MR scans. Alzheimer’s & Dementia, 2021; 17: 89-102. PMCID: PMC7923395
  86. Sathe G, Albert M, Darrow J, Atsushi Saito, Troncoso J, Pandey A, Moghekar. Quantitative proteomic profiling of the frontal cortex in Alzheimer’s disease. Journal of Neurochemistry, 2021; 10:111. PMCID: PMC7775912.
  87. Soldan A, Pettigrew C, Zhu Y, Wang M-C, Bilgel M, Hou Z, Lu H, Miller M, Albert M. Association of lifestyle activities with functional brain connectivity and relationship to cognitive reserve among older adults. Cerebral Cortex, 2021; 31: 5637-5651. PMCID: PMC8568002
  88. Yang Z, Nasrallah I, Shou H, Wen J, Doshi J, Habes M, Erus G, Abdulkadir A, Resnick S, Albert M, Maruff P, Fripp J, Morris J, Wolk D, Davatzikos C. A deep-learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure, Nature Communication, 2021; 12: 7065. PMCID: PMC8642554.



    2020
  89. Alm K, Faria A, Moghekar A, Pettigrew C, Soldan A, Mori S, Albert M, Bakker A. Medial temporal lobe white matter pathway variability is associated with individual differences in episodic memory in cognitively normal older adults. Neurobiology of Aging, 2020; 87: 78-88. PMCID: PMC7064393.
  90. Bashyam V, Erus G, Doshi J, Habes M, Nasrallah I, Truelove-Hill M, Srinivasan D, Mamourian L, Pomponion R Fan Y, Launer L, Masters C, Maruff P, Zhou C, Volzke H, Johnson S, Fripp J, Koutsouleris N, Sattherthwaite T, Wolf D, Gur R, Gur R, Morris J, Albert M, Grabe H, Resnick S, Bryan N, Wolk D, Shou H, Davatzikos C. MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide. Brain. 2020;143: 2312-2324 PMCID: PMC7364766
  91. ChanC, Soldan A, Pettigrew C, Wang  J,  Albert  M,  Rosenberg  P. Depressive symptoms and CSF Alzheimer’s disease biomarkers in relation of clinical symptom onset of mild cognitive impairment. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020; 24: 312016. PMCID: PMC7513625
  92. Koychev I, Vaci N, Bilgel M, An Y, Muniz G, Wong D, Gallacher J, Moghekar A, Albert M, Resnick S. Prediction of rapid amyloid and phosphorylated-tau accumulation in cognitively healthy individuals Alzheimer’s & Dementia, Diagnosis, Assessment and Disease Monitoring, 2020, 14: 804. PMCID: PMC7086102.
  93. KulasonS, Tward D, Brown T, Sicat C, Liu C, BakkerA, GallagherM, AlbertM, Miller M.
    Entorhinal and transentorhinal atrophy in preclinical Alzheimer’s disease. Frontiers of Neuroscience, 2020; 14: 804. PMCID: PMC7472871.
  94. LuoJ, Agboola F, GrantE, MastersC, AlbertM, JohnsonS, McDade E, Fagan A, BenzingerT, Hassenstab J, BatemanJ, Morris J, Perrin R, Chatwal J, Jucker M, Ghetti B, Cruchaga C, Graff-Radford N, Schofeld P, Mori H, Xiong C. Sequence of Alzheimer biomarker changes in cognitively normal adults: A cross-sectional study. Neurology, 2020; 95:e3104-3116. PMCID: PMC7734923
  95. Ning J, Cai C, Chen Y, Huang X, Wang MC. Semiparametric modelling and estimation of covariate-adjusted dependence between bivariate recurrent events. Biometrics. 2020; 76: 1229-1239. PMCID: PMC7384929
  96. Pettigrew C, Soldan A, Zhu Y, Qing C, Wang M-C, Moghekar A, Miller M, Singh B, Martinez O, Fletcher E, DeCarli C, Albert M. Cognitive reserve and rate of change in Alzheimer’s and cerebrovascular disease biomarkers among cognitively normal individuals. Neurobiology of Aging, 2020; 88: 33-41. PMCID: PMC7160864.
  97. Pettigrew C, Soldan A, Wang J, Wang M-C, Arthur K, Moghekar A, Gottesman R, Albert M.  Association of midlife vascular risk and AD biomarkerswith subsequent cognitive decline.  Neurology, 2020, 95: e3093-e3103. PMCID: PMC7734925. 
  98. Pomponio R, Erus G, Habes M, Doshi J, Srinivasan D, Mamourian E, Bashyam V, Nasrallah I, Satterthwaite T, Fan Y, Launer L, Masters C, Maruff P, Zhou C, Volzke H, Johnson S, Fripp J, Koutsouleris N, Wolff D, Gur R, Gur R, Morris J, Albert M, Grabe H, Resnick S, Bryan N, Wolk D, Shinohara R, Shou H, Davatzikos C. Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan. Neuroimage, 2020, 208:116450. PMCID: PMC6980790.
  99. Raghavan NS, Dumitrescu L, Mormino E, Mahoney E, LeeAJ, Gao Y, Bilgel M, Goldstein D, Harrison T, Engelman CD, Saykin AJ, Whelan CD, Liu JZ, Jagust W, Albert M, Johnson SC, Yang H, JohnsonK, Aisen P, Resnick SM, Sperling R, De Jager PL, The Alzheimer’s Disease Neuroimaging Initiative, Schneider J, Bennett DA, Schrag M, Vardarajan B, Hohman TJ, Mayeux R. Association between common variants in RBFOX1, an RNA binding protein, and brain amyloidosis in early and preclinical Alzheimer’s disease. JAMA Neurology, 2020, 77: 1-11. PMCID: PMC7309575.
  100. Sathe G, Manganaparthi K, Jain A, Darrow J, Troncoso J, Albert M, Moghekar A, Pandey A. Multiplexed phosphoproteomic study of brain in patients with Alzheimer’s disease and age-matched cognitively healthy controls. OMICS: A Journal of Integrative Biology, 2020; 24:216-227.  PMCID: PMC7366319.
  101. Soldan A, Pettigrew C, Xu, Y, Wang M-C, Moghekar A, Gottesman R, Singh B, Martinez O, Fletcher E, DeCarli C, Albert M. White matter hyperintensities and CSF AD biomarkers in preclinical Alzheimer’s disease. Neurology, 2020; 94: e950-e960. PMCID PMC7238945
  102. Soldan A, Pettigrew C, Albert M. Cognitive reserve from the perspective of preclinical Alzheimer’s disease: 2020 Update. Clin Geriatr Med, 2020; 36: 247-263. PMCID: PMC7838205
  103. Soldan A, Pettigrew C, ZhuY, WangM-C, GottesmanR, DeCarliC, AlbertM, Cognitive reserve and midlife vascular risk: cognitive and clinical outcomes. Annals of Clinical and Translational Neurology, 2020; 7: 1307-1317. PMCID: PMC7448143
  104. Sun Y, Chiou S, Wang MC. ROC-guided survival trees and ensembles. Biometrics. 2020, 76: 1177-1189. PMCID: PMC8491647
  105. Tward D, Brown T, Kageyama Y, Patel J, Hou Z, Mori S, Albert M, Troncoso J, Miller M. Diffeomorphic registration with intensity transformation and missing data: Application to 3D digital pathology of Alzheimer’s disease. Frontiers in Neuroscience, 2020; 14:1-18. PMCID: PMC7027169
  106. Walker KA, Gross AL, Moghekar AR, Soldan A, Pettigrew C, Hou X, Lu H, Alfini AJ, Bilgel M, Miller MI, Albert MS, Walston J. Association of peripheral inflammatory markers with connectivity in large-scale functional brain networks of non-demented older adults. Brain, Behavior, and Immunity, 2020, 87: 388-396. PMCID: PMC7316598.
  107. Wang Z, Tang Z, Zhu Y, Pettigrew C, Soldan A, Gross A, Albert M. AD risk score for the early phases of disease based on unsupervised machine learning. Alzheimers & Dementia, 2020; 16: 1524-1533. PMCID: PMC7666001.



    2019
  108. Blauwendraat C, Pletnikova O, GeigerJ, Murphy N, Abramson Y, Rudow G, Mamais A, Sabir M, Crain B, Ahmed S, Rosenthal L, Bakker C, Faghri F, Chia R, Ding J, Dawson T, Pantelyat A, Albert M, Nalls M, Resnick S, Ferrucci L, Cookson M, Hillis A, Troncoso J, Scholz S. Genetic analysis of neurodegenerative diseases in a pathology cohort. Neurobiol Aging, 2019; 76: 241 e1-214. PMCID: PMC6391207.
  109. Chan C, Soldan A, Pettigrew C, Wang M.C, Wang J, Albert M, Rosenberg P. Depressive symptoms in relation to clinical symptom onset of mild cognitive impairment. International Psychogeriatrics, 2019; 31: 561-569. PMCID: PMC6458104
  110. Gross AL, Walker K, Moghekar A, Pettigrew C, Soldan A, Albert M, Walston J. Plasma markers of inflammation linked to clinical progression and decline during preclinical AD. Frontiers of Aging Neuroscience, 2019; 11: 229. PMCID: PMC6742958
  111. Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Bennett DA, Schneider JA, Jefferson AL, Hohman TJ. Sex differences in the genetic predictors of Alzheimer’s pathology. Brain. 2019; 142:2581-2589.  PMCID: PMC6736148
  112. Kulason S, Tward DJ, Brown T, Sicat CS, Liu CF, Ratnanather JT, Younes L, Bakker A, Gallagher M, Albert M, Miller MI. Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment. Neuroimage Clinical. 2019; 21:101617. PMCID: PMC6412863.
  113. Lin Z, Sur S, Soldan A, Pettigrew C, Miller M, Oishi K, Moghekar A, Pillai J, Albert M, Lu H. Brain oxygen extraction using MRI in older individuals: relationship to apolipoprotein E genotype and amyloid burden. Radiology, 2019; 292:140-148. PMCID: PMC6604795.
  114. Liu C-F, Padhy S, Ramachandran S, Wang V, Efimov A, Bernal A, Shi L, Vaillant M, Ratnanather T, Caffo B, Albert M, Miller M. Using deep Siamese neural networks for detection of brain asymmetries associated with Alzheimer’s disease and mild cognitive impairment. Magnetic Resonance Imaging, 2019; 64: 190-199. PMCID: PMC6874905
  115. Pettigrew C, Soldan A. Defining cognitive reserve and implications for cognitive aging. Curr Neurol Neurosci Rep, 2019; 19: 1. PMCID: PMC30627880.
  116. Pettigrew C, Shao Y, Zhu Y, Grega  M, Brichko R, Wang M-C, Carlson M, Albert M, Soldan A. Self-reported lifestyle activities in relation to longitudinal cognitive trajectories. Alzheimer’s Disease & Associated Disorders, 2019; 33: 21-28. PMCID: PMC6389389
  117. Sathe G, Na C, Santosh R, Magunundu A, Albert M, Moghekar A, Pandey A. Quantitative proteomic profiling of cerebrospinal fluid to identify candidate biomarkers for Alzheimer’s disease. Proteomics Clinical Applications, 2019; 4: e1800105. PMCID: PMC6639119
  118. Soldan A, Moghekar A, Walker K, Pettigrew C, Hou Z, Lu H, Miller M, Alfini A, Albert M, Xu D, Xiao M-F, Worley P. Resting-state functional connectivity is associated with cerebrospinal fluid levels of the synaptic protein NPTX2 in non-demented older adults. Frontiers of Aging Neuroscience, 2019; 11:132. PMCID: PMC6568192.
  119. Soldan A, Pettigrew C, Fagan A, Schindler S, Moghekar A, Fowler C, Li Q-X, Collins S, Carlsson C, Asthana S, Masters C, Johnson S, Morris J, Albert M, Gross A. ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes. Neurology, 2019; 92: e1567-e1579. PMCID: PMC6448449
  120. Wu D, Albert M, Soldan A, Pettigrew C, Oishi K, Tomogane Y, Ye C, Ma T, Miller M, Mori S. Multi-atlas based detection and localization (MADL) for location-dependent quantification of white matter hyperintensities. Neuroimage Clinical, 2019; 22:101772. PMCID: PMC6444296.
  121. Xiong C, Luo J, Agboola F, Li Y, Albert M, Johnson S, Koscik R, Masters C, Soldan A, Villemagne V, Li Q-X, McDade E, Fagan A, Masoumzadeh P, Benzinger T, Hassenstab J, Bateman R, Morris J. A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer’s disease from young adulthood and designing prevention trials. Alzheimers Dementia, 2019; 15: 1448-1457. PMCID: PMC6874758
  122. Ye C, Albert M, Brown T, Bilgel M, Hsu J, Ma T, Caffo B, Miller M, Mori S, Oishi K. Extended multimodal whole-brain anatomical covariance analysis: detection of disrupted covariance networks related to amyloid deposition. Heliyon, 2019; e02074. PMCID: PMC6656959
  123. Younes L, Albert M, Moghekar A, Soldan A, Pettigrew C, Miller M. Identifying changepoints in biomarkers during the preclinical phase of Alzheimer’s disease. Frontiers of Aging Neuroscience, 2019; 11:74. PMCID: PMC6454004



    2018
  124. Albert M, Zhu Y, Moghekar A, Mori S, Miller M, Soldan A, Pettigrew C, Selnes O, Li S, Wang M-C. Predicting progression from normal cognition to mild cognitive impairment for individuals at 5 years. Brain, 2018, 141: 877-887. PMCID: PMC5837651.
  125. Deming Y, Dumitrescu L, Barnes L, Thambisetty M,  Kunkle B, Gifford K, Bush W, Chibnik L, Mukherjee S, DeJager P, Kukull W, Huentelman M, Crane P, Resnick S, Keen C, Montine T, Schellenberg G, Haines J, Zetterberg H, Blennow K, Larson E, Johnson S, Albert M, Moghekar A, DelAquila J, Fernandez M, Budde J, Hassenstab J, Fagan A, Riemenschneider M, Petersen R, Minthon L, Chao M, VanDeerlin V, Lee V, Shaw L, Trojanowski J, Peskind E, Li G, Davis L, Sealock J, Cox N, ADNI, ADGC, Goate A, Schneider J, Jefferson A, Cruchaga C, Hohman T. Sex-specific genetic predictors of Alzheimer’s disease biomarkers. Acta Neuropathologica, 2018; 136:857-872. PMCID: PMC6280657.
  126. Hohman T, Dumitrescu L, Barnes L, Thambisetty M, Beecham G, Kunkle B, Gifford K, Bush W, Chibnik L, Mukherjee S, De Jager P, Kukull W, Crane P, Resnick S, Keene C, Montine T, Schellenberg G, Haines J, Zetterberg H, Blennow K, Larson E, Johnson S, Albert M, Bennett D, Schneider J, Jefferson A. Sex-specific associations of apolipoprotein E with cerebrospinal fluid levels of tau. JAMA Neurology, 2018; 75: 989-998. PMCID: PMC6142927.
  127. Sathe G, Na C, Renuse S, Madugundu A, Albert M, Moghekar A, Pandey A. Phosphotyrosine profiling of human cerebrospinal fluid. Clinical Proteomics, 2018, 15: 29. PMCID: PMC6136184
  128. Soldan A, Pettigrew C, Albert M. Evaluating cognitive reserve through the prism of preclinical Alzheimer’s disease. Psychiatric Clinics of North America, 2018; 41: 65-77. PMCID: PMC5806143.



    2017
  129. Cai Q, Wang M-C, Chan KC. Joint modeling of longitudinal, recurrent events and failure time data for survivor’s population. Biometrics, 2017; 73: 1150-1160. PMCID: PMC5791160.
  130. Gross AL, Hassenstab J, Johnson S, Clark LR, Resnick SM, Kitner-Triolo M, Masters C, Maruff P, Morris JC, Soldan A, Pettigrew C, Albert M. A classification algorithm for predicting progression from normal cognition to mild cognitive impairment across five cohorts: The Preclinical AD Consortium. Alzheimer’s and Dementia: Diagnosis, Assessment & Disease Monitoring, 2017, 8: 147-155. PMCID: PMC5476965.
  131. Mori S, Kageyama Y, Hou Z, Aggarwal M, Patel J, Brown T, Miller M, Wu D, Troncoso J. Elucidation of white matter tracts of the human amygdala by detailed comparison between high-resolution postmortem magnetic resonance imaging and histology. Frontiers of Neuroanatomy, 2017; 11: 16. PMCID: PMC5348491
  132. Pettigrew C, Soldan A, Zhu Y, Wang M-C, Brown T, Miller M, Albert M. Cognitive reserve and cortical thickness in preclinical Alzheimer’s disease. Brain Imaging and Behavior, 2017; 11:357-367. PMCID: PMC5577409.
  133. Pettigrew C, Soldan A, Sloane K, Cai Q, Wang J, Wang M-C, Moghekar A, Miller M, Albert M. Progressive medial temporal lobe atrophy during preclinical Alzheimer’s disease. NeuroImage Clinical, 2017, 16:439-446. PMCID: PMC5577409.
  134. Sacktor N, Soldan A, Grega M, Farrington L, Cai Q, Wang, M-C, Gottesman R, Turner RS, Albert M. The BIOCARD Index: A summary measure to predict onset of mild cognitive impairment. Alzheimer Disease & Associated Disorders, 2017; 31:114-119. PMCID: PMC5443710
  135. Soldan A, Pettigrew C, Cai Q, Wang J, Wang MC, Moghekar A, Miller M, Albert M. Cognitive reserve and long-term change in cognition in aging and preclinical Alzheimer’s disease. Neurobiology of Aging, 2017: 60: 164-172. PMCID: PMC5679465.
  136. Tward D, Sicat C, Brown T, Bakker A, Gallagher M, Albert M, Miller M. Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal morphometry. Alzheimers & Dementia, 2017; 9: 41-50. PMCID: PMC5608074
  137. Varma V, Varma S, An Y, Hohman T, Casanova R, Beri A, Dammer E, Seyfried N, Pletnikova O, Moghekar A, Wilson M, Lah J, O’Brien R, Levey A, Troncoso J, Albert M, Thambisetty M. Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway. Molecular Psychiatry, 2017; 22: 13-23. PMCID: PMC5726508.



    2016
  138. Arguillere S, Miller M, Younes L. Diffeomorphic surface registration with atrophy constraints. SIAM J Imaging Sci, 2016; 9: 975-1003. PMCID: PMC9148198.
  139. Gross AL, Mungas D, Leoutsakos J, Albert M, Jones RN. Alzheimer’s disease severity, objectively determined and measured. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2016; 4: 159-168. PMCID: PMC5078784
  140. Leoutsakos J-M, Gross AL, Jones RN, Albert M, Breitner JC. Alzheimer’s progression score: development of a biomarker summary outcome for AD prevention trials. Journal of Prevention of Alzheimer’s Disease, 2016; 3: 229-235.  PMCID: PMC5639716.
  141. Pettigrew C, Soldan A, Zhu Y, Wang M-C, Moghekar A, Brown T, Miller M, Albert M. Cortical thickness in relation to clinical symptom onset in preclinical AD. Neuroimage Clinical, 2016; 12: 116-122. PMCID: PMC4932610.
  142. Soldan A, Pettigrew C, Cai Q, Wang M-C, Moghekar A, O’Brien R, Albert M. Hypothetical preclinical AD groups and longitudinal cognitive change. JAMA Neurol, 2016; 73:698-705. PMCID: PMC5173327.
  143. Soldan, A, Pettigrew C, Moghekar A, Albert M. Computerized cognitive tests are associated with biomarkers of Alzheimer’s disease in cognitively normal individuals 10 years prior. J Intl Neuropsychol Soc, 2016; 22:968-977. PMCID: PMC5154173
  144. Wennberg A, Spira A, Pettigrew C, Soldan A, Zipunnikov V, Rebok G, Roses A, Lutz M, Miller M,  Thambisetty M, Albert M.  Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults. Neurological Sciences, 2016; 365: 89-95. PMCID: PMC4876973



    2015
  145. Miller MI, Ratnanather J, Tward D, Brown T, Lee D, Ketcha M, Mori K, Wang M-C, Mori S, Albert M, Younes L. Network degeneration in Alzheimer’s disease via MRI based shape diffeomorphometry and high-field atlasing. Frontiers in Bioengineering and Biotechnology, 2015, 3:54. PMCID: PMC4515983.
  146. Miller MI, Younes L, Ratnanather T, Brown T, Trinh H, Lee DS, Tward D, Mahon PB, Mori S, Albert M. Amygdalar atrophy in symptomatic Alzheimer’s disease based on diffeomorphometry: the BIOCARD cohort. Neurobiology of Aging, 2015; 36 (Suppl 1): S3-S10. PMCID: PMC4271320.
  147. Pettigrew C, Soldan A, Moghekar A, Wang M-C, Gross A, O’Brien R, Albert M. Relationship between cerebrospinal fluid biomarkers of Alzheimer’s disease and cognition in cognitively normal older adults. Neuropsychologia, 2015, 78:63-72. PMCID: PMC4630154. 
  148. Resnick S, Bilgel M, Moghekar A, An Y, Cai Q, Wang M-C, Thambisetty M, Prince J, Zhou Y, Soldan A, Wong D, O’Brien R, Ferrucci L, Albert M. Changes in Abeta biomarkers and associations with ApoE genotype in two longitudinal cohorts. Neurobiol Aging 2015,36: 2333-2339. PMCID: PMC5084914
  149. Soldan A, Pettigrew C, Lu Y, Wang M-C, Selnes O, Albert, A, Brown T, Ratnanather T, Younes L, Miller M. Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical AD, Human Brain Mapping, 2015, 36: 2826-2841. PMCID: PMC4478167.
  150. Tang X, Crochetti D, Kutten K, Ceritoglu C, Albert M, Mori S, Mostofsky S, Miller M. Segmentation of brain magnetic resonance images based on multi-atlas likelihood fusion: testing using data with a broad range of anatomical and photometric profiles. Frontiers in Neuroscience, 2015, 9: 61. PMCID: PMC4347448.
  151. Toledo J, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chaivetto L, Rami L, Hansson O, Sperling R, Engelboroghs S, Osorio R, Vanderstichele H, Vandijck M, Hampel H, Teipl S, Moghekar A, Albert M, Hu W, Monge Argiles J, Gorostidi A, Teunissen C, De Deyn PP, Hyman B, Molineuvo J, Frisoni G, Linazasoro G, de Leon M, van der Flier W, Scheltens P, Blennow K, Shaw L, Trojanowski J. Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain 2015; 138: 2701-2715. PMCID: PMC4643624



    2014
  152. Albert M, Soldan A, Gottesman R, McKhann G, Sacktor N, Farrington L, Grega M, Turner R, Lu Y, Li S, Wang MC, Selnes O. Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype. Current Alzheimers Research, 2014, 11: 773-784. PMCID: PMC4163954.
  153. Miller M, Younes L, Ratnanather J, Brown T, Trinh H, Lee D, Tward D, Mahon P, Mori S, Albert M. Amydalar atrophy in symptomatic AD based on diffeomorphometry: the BIOCARD cohort. Neurobiol Aging, 2014; 36: S3-S10. PMCID: PMC4271320. 
  154. Semba R, Moghekar A, Hu J, Sun K, Turner R, Ferrucci L, O’Brien R. Klotho in the cerebrospinal fluid of adults with and without Alzheimer’s disease. Neurosci Lett, 2014; 558: 37-40. PMCID: PMC4037850
  155. Younes L, Albert M, Miller M. Inferring changepoint times of medial temporal lobe morphometric change in preclinical Alzheimer’s disease. NeuroImage, 2014, 5: 178-187. PMCID: PMC4110355.



    2013
  156. Li S, Okonkwo O, Albert M, Wang MC. Variation in variables that predict progression from MCI to AD dementia over the duration of follow-up. Amer J Alzheimers Dis, 2013; 1: 12-28. PMCID: PMC3919474.
  157. Liu X, Jin Z, O’Brien R, Bathon J, Dietz HC, Grote E, Van Eyk JE. Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms. Methods, 2013; 61: 304-312. PMCID: PMC3990191.
  158. Miller MI, Younes L, Ratnanather JT,  Brown T, Trinh H, Postell E, Lee DS, Wang M-C, Mori S, O’Brien R, Albert M. The diffeomorphometry of temporal lobe structures in preclinical Alzheimer’s disease. NeuroImage  Clinical, 2013; 3: 352-360.PMCID: PMC3863771.
  159. Moghekar A, Li S, Lu Y, Li M, Wang MC, Albert M, O’Brien R. CSF biomarker changes precede symptom onset of mild cognitive impairment. Neurology. 2013; 81: 1753-1758. PMCID: PMC3821715.
  160. Pettigrew C, Soldan A, Li S, Lu Y, Wang MC, Selnes OA, Moghekar A, O’Brien R, Albert M. Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer’s disease. Cogn Neurosci. 2013; 4: 136-142. PMCID: PMC3836845.
  161. Soldan A, Pettigrew C, Li S, Wang MC, Moghekar A, Selnes OA, Albert M, O’Brien R. Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer’s disease. Neurobiol Aging. 2013; 34: 2827-2834. PMCID: PMC3823238.
  162. Wang M-C, Li S. ROC analysis for multiple markers with tree-based classification.  Journal of Lifetime Data Analysis 2013; 19:79-99.  PMCID: PMC3633731.



    2012
  163. Miller MI, Younes L, Ratnanather JT, Brown T, Reigel T, Trinh H, Tang Z, Barker P, Mori S. Albert M. Amygdala atrophy in MCI/Alzheimer’s disease in the BIOCARD cohort based on diffeomorphic morphometry. Med Image Comput Assist Interv, 2012; 155-166. PMCID: PMC4063307. 
  164. Moghekar A, Goh J, Li M, Tang X, Albert M, O’Brien R. Cerebrospinal fluid Aß peptide and tau levels show little fluctuation in older subjects. Arch Neurol, 2012; 69: 246-250. PMCID: PMC3310240.
  165. Wang M-C, Li S.  Bivariate marker measurements and ROC analysis. Biometrics, 2012; 68: 1207–1218. PMCID: PMC3530667. 



    2011
  166. Okonkwo OC, Mielke MM, Griffith HR, Moghekar AR, O’Brien RJ, Shaw LM, Trojanowski JQ, Albert MS, the Alzheimer’s Disease Neuroimaging Initiative. Cerebrospinal fluid profiles predict prospective course and outcome among persons with amnestic mild cognitive impairment. Arch Neurol 2011, 68: 113-119. PMCID: PMC3058271.
  167. Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Llado A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O’Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schroder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K. The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers & Dementia. 2011; 7: 386-395. PMCID: PMC3710290.